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{
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{
            
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  "author": "Van de Waal, Dedmer B",
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  "author": "Van de Waal, Dedmer B",
            
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  "author_email": "",
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  "author_email": "",
            
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  "citation": [],
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  "citation": [],
            
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  "creator_user_id": "17755db4-395a-4b3b-ac09-e8e3484ca700",
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  "creator_user_id": "17755db4-395a-4b3b-ac09-e8e3484ca700",
            
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  "doi": "10.1594/PANGAEA.835715",
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  "doi": "10.1594/PANGAEA.835715",
            
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  "doi_date_published": "2014",
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  "doi_date_published": "2014",
            
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  "doi_publisher": "",
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  "doi_publisher": "",
            
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  "doi_status": "True",
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  "doi_status": "True",
            
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  "extra_authors": [
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  "extra_authors": [
            
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    {
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    {
            
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      "extra_author": "Eberlein, Tim",
12
      "extra_author": "Eberlein, Tim",
            
13
      "familyName": "Eberlein",
13
      "familyName": "Eberlein",
            
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      "givenName": "Tim",
14
      "givenName": "Tim",
            
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      "orcid": ""
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      "orcid": ""
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "John, Uwe",
18
      "extra_author": "John, Uwe",
            
19
      "familyName": "John",
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      "familyName": "John",
            
20
      "givenName": "Uwe",
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      "givenName": "Uwe",
            
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      "orcid": "0000-0002-1297-4086"
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      "orcid": "0000-0002-1297-4086"
            
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    },
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    },
            
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    {
23
    {
            
24
      "extra_author": "Wohlrab, Sylke",
24
      "extra_author": "Wohlrab, Sylke",
            
25
      "familyName": "Wohlrab",
25
      "familyName": "Wohlrab",
            
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      "givenName": "Sylke",
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      "givenName": "Sylke",
            
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      "orcid": "0000-0003-3190-0880"
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      "orcid": "0000-0003-3190-0880"
            
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    },
28
    },
            
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    {
29
    {
            
30
      "extra_author": "Rost, Bj\u00f6rn",
30
      "extra_author": "Rost, Bj\u00f6rn",
            
31
      "familyName": "Rost",
31
      "familyName": "Rost",
            
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      "givenName": "Bj\u00f6rn",
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      "givenName": "Bj\u00f6rn",
            
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      "orcid": "0000-0001-5452-5505"
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      "orcid": "0000-0001-5452-5505"
            
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    }
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    }
            
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  ],
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  ],
            
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  "familyName": "Van de Waal",
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  "familyName": "Van de Waal",
            
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  "givenName": "Dedmer B",
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  "givenName": "Dedmer B",
            
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  "groups": [],
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  "groups": [],
            
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  "id": "b0f87659-2fa1-45c6-b6a2-7c93fdfb2dd4",
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  "id": "b0f87659-2fa1-45c6-b6a2-7c93fdfb2dd4",
            
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  "isopen": false,
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  "isopen": false,
            
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  "license_id": "CC-BY-3.0",
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  "license_id": "CC-BY-3.0",
            
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  "license_title": "CC-BY-3.0",
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  "license_title": "CC-BY-3.0",
            
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  "metadata_created": "2024-11-29T11:45:12.697415",
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  "metadata_created": "2024-11-29T11:45:12.697415",
            
n
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  "metadata_modified": "2024-11-29T11:45:12.697421",
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  "metadata_modified": "2024-11-30T10:41:36.831774",
            
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  "name": "png-doi-10-1594-pangaea-835715",
45
  "name": "png-doi-10-1594-pangaea-835715",
            
46
  "notes": "Ocean acidification is considered a major threat to marine 
46
  "notes": "Ocean acidification is considered a major threat to marine 
            
47
ecosystems and may particularly affect primary producers. Here we 
47
ecosystems and may particularly affect primary producers. Here we 
            
48
investigated the impact of elevated pCO2 on paralytic shellfish 
48
investigated the impact of elevated pCO2 on paralytic shellfish 
            
49
poisoning toxin (PST) content and composition in two strains of 
49
poisoning toxin (PST) content and composition in two strains of 
            
50
Alexandrium tamarense, Alex5 and Alex2. Experiments were carried out 
50
Alexandrium tamarense, Alex5 and Alex2. Experiments were carried out 
            
51
as dilute batch to keep carbonate chemistry unaltered over time. We 
51
as dilute batch to keep carbonate chemistry unaltered over time. We 
            
52
observed only minor changes with respect to growth and elemental 
52
observed only minor changes with respect to growth and elemental 
            
53
composition in response to elevated pCO2. For both strains, the 
53
composition in response to elevated pCO2. For both strains, the 
            
54
cellular PST content, and in particular the associated cellular 
54
cellular PST content, and in particular the associated cellular 
            
55
toxicity, was lower in the high CO2 treatments. In addition, Alex5 
55
toxicity, was lower in the high CO2 treatments. In addition, Alex5 
            
56
showed a shift in its PST composition from a nonsulfated analogue 
56
showed a shift in its PST composition from a nonsulfated analogue 
            
57
towards less toxic sulfated analogues with increasing pCO2. 
57
towards less toxic sulfated analogues with increasing pCO2. 
            
58
Transcriptomic analyses suggest that the ability of A. tamarense to 
58
Transcriptomic analyses suggest that the ability of A. tamarense to 
            
59
maintain cellular homeostasis is predominantly regulated on the 
59
maintain cellular homeostasis is predominantly regulated on the 
            
60
post-translational level rather than on the transcriptomic level. 
60
post-translational level rather than on the transcriptomic level. 
            
61
Furthermore, genes associated to secondary metabolite and amino acid 
61
Furthermore, genes associated to secondary metabolite and amino acid 
            
62
metabolism in Alex5 were down-regulated in the high CO2 treatment, 
62
metabolism in Alex5 were down-regulated in the high CO2 treatment, 
            
63
which may explain the lower PST content. Elevated pCO2 also induced 
63
which may explain the lower PST content. Elevated pCO2 also induced 
            
64
up-regulation of a putative sulfotransferase sxtN homologue and a 
64
up-regulation of a putative sulfotransferase sxtN homologue and a 
            
65
substantial down-regulation of several sulfatases. Such changes in 
65
substantial down-regulation of several sulfatases. Such changes in 
            
66
sulfur metabolism may explain the shift in PST composition towards 
66
sulfur metabolism may explain the shift in PST composition towards 
            
67
more sulfated analogues. All in all, our results indicate that 
67
more sulfated analogues. All in all, our results indicate that 
            
68
elevated pCO2 will have minor consequences for growth and elemental 
68
elevated pCO2 will have minor consequences for growth and elemental 
            
69
composition, but may potentially reduce the cellular toxicity of A. 
69
composition, but may potentially reduce the cellular toxicity of A. 
            
70
tamarense.",
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tamarense.",
            
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  "num_resources": 0,
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  "num_resources": 0,
            
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  "num_tags": 14,
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  "orcid": "0000-0001-8803-1247",
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  "orcid": "0000-0001-8803-1247",
            
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  "organization": {
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  "organization": {
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "created": "2024-11-29T11:32:00.143130",
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    "created": "2024-11-30T10:25:26.439072",
            
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    "description": "PANGAEA (Data Publisher for Earth & Environmental 
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    "description": "PANGAEA (Data Publisher for Earth & Environmental 
            
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Science): The information system PANGAEA is operated as an Open Access 
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Science): The information system PANGAEA is operated as an Open Access 
            
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library aimed at archiving, publishing and distributing georeferenced 
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library aimed at archiving, publishing and distributing georeferenced 
            
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data from earth system research. PANGAEA guarantees long-term 
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data from earth system research. PANGAEA guarantees long-term 
            
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availability (greater than 10 years) of its content. PANGAEA is open 
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availability (greater than 10 years) of its content. PANGAEA is open 
            
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to any project, institution, or individual scientist to use or to 
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to any project, institution, or individual scientist to use or to 
            
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archive and publish data. PANGAEA focuses on georeferenced 
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archive and publish data. PANGAEA focuses on georeferenced 
            
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observational data, experimental data, and models/simulations. 
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observational data, experimental data, and models/simulations. 
            
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Citability, comprehensive metadata descriptions, interoperability of 
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Citability, comprehensive metadata descriptions, interoperability of 
            
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data and metadata, a high degree of structural and semantic 
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data and metadata, a high degree of structural and semantic 
            
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harmonization of the data inventory as well as the commitment of the 
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harmonization of the data inventory as well as the commitment of the 
            
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hosting institutions ensures FAIRness of archived data.",
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hosting institutions ensures FAIRness of archived data.",
            
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    "id": "c2816fc6-b5ce-42c9-b5a4-11709b658b82",
            
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    "image_url": "pangaea_topicbiosphere.png",
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    "image_url": "pangaea_topicecology.png",
            
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    "is_organization": true,
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    "is_organization": true,
            
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    "name": "pangaea_biosphere",
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    "name": "pangaea_ecology",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "PANGAEA (Biosphere)",
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    "title": "PANGAEA (Ecology)",
            
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    "type": "organization"
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    "type": "organization"
            
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  },
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  },
            
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  "owner_org": "3226ef9c-20d1-43fd-ba8f-fa35c8c9fb5d",
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  "owner_org": "c2816fc6-b5ce-42c9-b5a4-11709b658b82",
            
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  "private": false,
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  "private": false,
            
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  "publication_year": "2014",
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  "publication_year": "2014",
            
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  "related_identifiers": [
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  "related_identifiers": [
            
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    {
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    {
            
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      "authors": "Van de Waal Dedmer B,Eberlein Tim,John Uwe,Wohlrab 
102
      "authors": "Van de Waal Dedmer B,Eberlein Tim,John Uwe,Wohlrab 
            
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Sylke,Rost Bj\u00f6rn",
103
Sylke,Rost Bj\u00f6rn",
            
104
      "email_authors": 
104
      "email_authors": 
            
105
ioo.knaw.nl,,uwe.john@awi.de,sylke.wohlrab@awi.de,bjoern.rost@awi.de",
105
ioo.knaw.nl,,uwe.john@awi.de,sylke.wohlrab@awi.de,bjoern.rost@awi.de",
            
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      "identifier": "https://doi.org/10.1016/j.toxicon.2013.11.011",
106
      "identifier": "https://doi.org/10.1016/j.toxicon.2013.11.011",
            
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      "identifier_type": "DOI",
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      "identifier_type": "DOI",
            
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      "orcid_authors": 
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      "orcid_authors": 
            
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03-1247,,0000-0002-1297-4086,0000-0003-3190-0880,0000-0001-5452-5505",
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03-1247,,0000-0002-1297-4086,0000-0003-3190-0880,0000-0001-5452-5505",
            
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      "relation_type": "IsSupplementTo",
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      "relation_type": "IsSupplementTo",
            
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      "source": "Toxicon",
111
      "source": "Toxicon",
            
112
      "title": "Impact of elevated pCO2 on paralytic shellfish 
112
      "title": "Impact of elevated pCO2 on paralytic shellfish 
            
113
poisoning toxin content and composition in Alexandrium tamarense",
113
poisoning toxin content and composition in Alexandrium tamarense",
            
114
      "year": "2014"
114
      "year": "2014"
            
115
    },
115
    },
            
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    {
116
    {
            
117
      "authors": "Lavigne H\u00e9lo\u00efse,Epitalon 
117
      "authors": "Lavigne H\u00e9lo\u00efse,Epitalon 
            
118
Jean-Marie,Gattuso Jean-Pierre",
118
Jean-Marie,Gattuso Jean-Pierre",
            
119
      "email_authors": 
119
      "email_authors": 
            
120
"hlavigne@naturalsciences.be,,jean-pierre.gattuso@imev-mer.fr",
120
"hlavigne@naturalsciences.be,,jean-pierre.gattuso@imev-mer.fr",
            
121
      "identifier": "https://cran.r-project.org/package=seacarb",
121
      "identifier": "https://cran.r-project.org/package=seacarb",
            
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      "identifier_type": "DOI",
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      "identifier_type": "DOI",
            
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      "orcid_authors": ",,0000-0002-4533-4114",
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      "orcid_authors": ",,0000-0002-4533-4114",
            
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      "relation_type": "References",
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      "relation_type": "References",
            
125
      "source": "",
125
      "source": "",
            
126
      "title": "seacarb: seawater carbonate chemistry with R. R 
126
      "title": "seacarb: seawater carbonate chemistry with R. R 
            
127
package version 3.0",
127
package version 3.0",
            
128
      "year": "2014"
128
      "year": "2014"
            
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    }
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    }
            
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  ],
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  ],
            
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  "relationships_as_object": [],
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  "relationships_as_object": [],
            
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  "relationships_as_subject": [],
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  "relationships_as_subject": [],
            
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  "repository_name": "PANGAEA (Data Publisher for Earth & 
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  "repository_name": "PANGAEA (Data Publisher for Earth & 
            
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Environmental Science)",
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Environmental Science)",
            
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  "resource_type": "text/tab-separated-values - filename: 
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  "resource_type": "text/tab-separated-values - filename: 
            
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Van_de_Waal_2013",
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Van_de_Waal_2013",
            
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  "resources": [],
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  "resources": [],
            
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  "source_metadata_created": "2014",
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  "source_metadata_created": "2014",
            
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  "source_metadata_modified": "",
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  "source_metadata_modified": "",
            
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  "state": "active",
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  "state": "active",
            
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  "subject_areas": [
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "BiologicalClassification"
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      "subject_area_name": "BiologicalClassification"
            
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    },
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    },
            
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    {
146
    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
148
      "subject_area_name": "Biosphere"
148
      "subject_area_name": "Biosphere"
            
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    },
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    },
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Chemistry"
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      "subject_area_name": "Chemistry"
            
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    },
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    },
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Ecology"
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      "subject_area_name": "Ecology"
            
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    }
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    }
            
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  ],
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  ],
            
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  "tags": [
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  "tags": [
            
160
    {
160
    {
            
161
      "display_name": "Alexandrium tamarense",
161
      "display_name": "Alexandrium tamarense",
            
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      "id": "109b99a5-de87-4fee-b6bc-47bc6db57ab9",
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      "id": "109b99a5-de87-4fee-b6bc-47bc6db57ab9",
            
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      "name": "Alexandrium tamarense",
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      "name": "Alexandrium tamarense",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
n
n
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      "display_name": "Aquaria 20 L",
            
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      "id": "62c412c1-2294-406a-ad79-183330400def",
            
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      "name": "Aquaria 20 L",
            
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
            
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    {
            
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      "display_name": "Bottles or small containers-Aquaria 20 L",
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      "display_name": "Bottles or small containers",
            
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      "id": "be154617-73a3-4ed4-b54f-69e22323c12a",
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      "id": "ba227243-af91-4efc-8086-790112e90e09",
            
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      "name": "Bottles or small containers-Aquaria 20 L",
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      "name": "Bottles or small containers",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "Chromista",
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      "display_name": "Chromista",
            
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      "id": "36ecf721-e11a-4662-8783-da539c625d5c",
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      "id": "36ecf721-e11a-4662-8783-da539c625d5c",
            
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      "name": "Chromista",
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      "name": "Chromista",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
188
    {
            
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      "display_name": "Gene expression incl. proteomics",
189
      "display_name": "Gene expression incl. proteomics",
            
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      "id": "a266e76f-1f2a-427a-97e6-8e248d591f17",
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      "id": "a266e76f-1f2a-427a-97e6-8e248d591f17",
            
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      "name": "Gene expression incl. proteomics",
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      "name": "Gene expression incl. proteomics",
            
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    {
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    {
            
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    {
            
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      "name": "Photosynthesis",
            
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    {
            
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      "id": "9c357867-c046-43fa-ad3e-39f612d5622b",
            
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      "name": "Phytoplankton",
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      "state": "active",
            
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    },
            
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    {
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    {
            
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      "name": "Primary production",
            
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    {
            
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      "display_name": "Self",
            
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      "name": "Self",
            
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "Single species",
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      "display_name": "Single species",
            
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      "id": "88de69be-3bdd-4cf8-b6a1-386d72c5888d",
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      "id": "88de69be-3bdd-4cf8-b6a1-386d72c5888d",
            
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      "name": "Single species",
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      "name": "Single species",
            
t
t
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      "state": "active",
            
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    },
            
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    {
            
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      "display_name": "protection",
            
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      "id": "64486a5e-aa52-4a3a-9426-fbcf2e3c2721",
            
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      "name": "protection",
            
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      "state": "active",
            
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      "vocabulary_id": null
            
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    }
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    }
            
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  ],
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  ],
            
259
  "title": "Impact of elevated pCO2 on paralytic shellfish poisoning 
294
  "title": "Impact of elevated pCO2 on paralytic shellfish poisoning 
            
260
toxin content and composition in Alexandrium tamarense",
295
toxin content and composition in Alexandrium tamarense",
            
261
  "type": "vdataset",
296
  "type": "vdataset",
            
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  "url": "https://doi.org/10.1594/PANGAEA.835715"
297
  "url": "https://doi.org/10.1594/PANGAEA.835715"
            
263
}
298
}