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{
            
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  "author": "Liu, Saixi",
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  "author": "Liu, Saixi",
            
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  "author_email": "",
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  "author_email": "",
            
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  "citation": [],
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  "citation": [],
            
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  "creator_user_id": "17755db4-395a-4b3b-ac09-e8e3484ca700",
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  "creator_user_id": "17755db4-395a-4b3b-ac09-e8e3484ca700",
            
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  "doi": "10.1594/PANGAEA.861971",
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  "doi": "10.1594/PANGAEA.861971",
            
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  "doi_date_published": "2016",
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  "doi_date_published": "2016",
            
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  "doi_publisher": "",
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  "doi_publisher": "",
            
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  "doi_status": "True",
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  "doi_status": "True",
            
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  "extra_authors": [
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  "extra_authors": [
            
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    {
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    {
            
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      "extra_author": "Shi, Wei",
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      "extra_author": "Shi, Wei",
            
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      "familyName": "Shi",
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      "familyName": "Shi",
            
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      "givenName": "Wei",
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      "givenName": "Wei",
            
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      "orcid": "0000-0003-0811-2165"
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      "orcid": "0000-0003-0811-2165"
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Guo, Cheng",
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      "extra_author": "Guo, Cheng",
            
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      "familyName": "Guo",
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      "familyName": "Guo",
            
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      "givenName": "Cheng",
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      "givenName": "Cheng",
            
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      "orcid": ""
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      "orcid": ""
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Zhao, Xinguo",
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      "extra_author": "Zhao, Xinguo",
            
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      "familyName": "Zhao",
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      "familyName": "Zhao",
            
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      "givenName": "Xinguo",
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      "givenName": "Xinguo",
            
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      "orcid": "0000-0001-5613-4620"
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      "orcid": "0000-0001-5613-4620"
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Han, Yu",
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      "extra_author": "Han, Yu",
            
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      "familyName": "Han",
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      "familyName": "Han",
            
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      "givenName": "Yu",
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      "givenName": "Yu",
            
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      "orcid": ""
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      "orcid": ""
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Peng, Chao",
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      "extra_author": "Peng, Chao",
            
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      "familyName": "Peng",
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      "familyName": "Peng",
            
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      "givenName": "Chao",
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      "givenName": "Chao",
            
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      "orcid": ""
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      "orcid": ""
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Chai, Xueliang",
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      "extra_author": "Chai, Xueliang",
            
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      "familyName": "Chai",
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      "familyName": "Chai",
            
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      "givenName": "Xueliang",
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      "givenName": "Xueliang",
            
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      "orcid": ""
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      "orcid": ""
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Liu, Guangxu",
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      "extra_author": "Liu, Guangxu",
            
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      "familyName": "Liu",
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      "familyName": "Liu",
            
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      "givenName": "Guangxu",
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      "givenName": "Guangxu",
            
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      "orcid": "0000-0002-1039-7801"
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      "orcid": "0000-0002-1039-7801"
            
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    }
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    }
            
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  ],
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  ],
            
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  "familyName": "Liu",
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  "familyName": "Liu",
            
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  "givenName": "Saixi",
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  "givenName": "Saixi",
            
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  "groups": [],
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  "license_id": "CC-BY-3.0",
            
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  "license_title": "CC-BY-3.0",
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  "license_title": "CC-BY-3.0",
            
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  "metadata_created": "2024-11-29T10:27:10.683736",
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  "metadata_modified": "2024-11-29T10:27:10.683742",
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  "metadata_modified": "2024-11-30T11:51:54.967660",
            
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  "name": "png-doi-10-1594-pangaea-861971",
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  "name": "png-doi-10-1594-pangaea-861971",
            
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  "notes": "The impact of pCO2 driven ocean acidification on marine 
64
  "notes": "The impact of pCO2 driven ocean acidification on marine 
            
65
bivalve immunity remains poorly understood. To date, this impact has 
65
bivalve immunity remains poorly understood. To date, this impact has 
            
66
only been investigated in a few bivalve species and the underlying 
66
only been investigated in a few bivalve species and the underlying 
            
67
molecular mechanism remains unknown. In the present study, the effects 
67
molecular mechanism remains unknown. In the present study, the effects 
            
68
of the realistic future ocean pCO2 levels (pH at 8.1, 7.8, and 7.4) on 
68
of the realistic future ocean pCO2 levels (pH at 8.1, 7.8, and 7.4) on 
            
69
the total number of haemocyte cells (THC), phagocytosis status, blood 
69
the total number of haemocyte cells (THC), phagocytosis status, blood 
            
70
cell types composition, and expression levels of twelve genes from the 
70
cell types composition, and expression levels of twelve genes from the 
            
71
NF-kappa beta signaling and toll-like receptor pathways of a typical 
71
NF-kappa beta signaling and toll-like receptor pathways of a typical 
            
72
bottom burrowing bivalve, blood clam (Tegillarca granosa), were 
72
bottom burrowing bivalve, blood clam (Tegillarca granosa), were 
            
73
investigated. The results obtained showed that while both THC number 
73
investigated. The results obtained showed that while both THC number 
            
74
and phagocytosis frequency were significantly reduced, the percentage 
74
and phagocytosis frequency were significantly reduced, the percentage 
            
75
of red and basophil granulocytes were significantly decreased and 
75
of red and basophil granulocytes were significantly decreased and 
            
76
increased, respectively, upon exposure to elevated pCO2. In addition, 
76
increased, respectively, upon exposure to elevated pCO2. In addition, 
            
77
exposure to pCO2 acidified seawater generally led to a significant 
77
exposure to pCO2 acidified seawater generally led to a significant 
            
78
down-regulation in the inducer and key response genes of NF-kappa beta 
78
down-regulation in the inducer and key response genes of NF-kappa beta 
            
79
signaling and toll-like receptor pathways. The results of the present 
79
signaling and toll-like receptor pathways. The results of the present 
            
80
study revealed that ocean acidification may hamper immune responses of 
80
study revealed that ocean acidification may hamper immune responses of 
            
81
the bivalve T. granosa which subsequently render individuals more 
81
the bivalve T. granosa which subsequently render individuals more 
            
82
susceptible to pathogens attacks such as those from virus and 
82
susceptible to pathogens attacks such as those from virus and 
            
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bacteria.",
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bacteria.",
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "description": "PANGAEA (Data Publisher for Earth & Environmental 
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    "description": "PANGAEA (Data Publisher for Earth & Environmental 
            
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Science): The information system PANGAEA is operated as an Open Access 
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Science): The information system PANGAEA is operated as an Open Access 
            
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library aimed at archiving, publishing and distributing georeferenced 
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library aimed at archiving, publishing and distributing georeferenced 
            
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data from earth system research. PANGAEA guarantees long-term 
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data from earth system research. PANGAEA guarantees long-term 
            
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availability (greater than 10 years) of its content. PANGAEA is open 
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availability (greater than 10 years) of its content. PANGAEA is open 
            
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to any project, institution, or individual scientist to use or to 
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to any project, institution, or individual scientist to use or to 
            
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archive and publish data. PANGAEA focuses on georeferenced 
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archive and publish data. PANGAEA focuses on georeferenced 
            
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observational data, experimental data, and models/simulations. 
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observational data, experimental data, and models/simulations. 
            
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Citability, comprehensive metadata descriptions, interoperability of 
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Citability, comprehensive metadata descriptions, interoperability of 
            
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data and metadata, a high degree of structural and semantic 
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data and metadata, a high degree of structural and semantic 
            
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harmonization of the data inventory as well as the commitment of the 
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harmonization of the data inventory as well as the commitment of the 
            
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hosting institutions ensures FAIRness of archived data.",
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hosting institutions ensures FAIRness of archived data.",
            
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    "id": "ce65c98e-83d7-4b4f-9db3-99759a987d6c",
            
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    "image_url": "pangaea_topicfisheries.png",
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    "image_url": "pangaea_topicoceans.png",
            
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    "is_organization": true,
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    "is_organization": true,
            
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    "name": "pangaea_fisheries",
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    "name": "pangaea_oceans",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "PANGAEA (Fisheries)",
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    "title": "PANGAEA (Oceans)",
            
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    "type": "organization"
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    "type": "organization"
            
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  },
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  },
            
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  "owner_org": "20afc080-b4a5-4502-8b78-b6a6cbb1e8eb",
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  "private": false,
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  "publication_year": "2016",
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  "publication_year": "2016",
            
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  "related_identifiers": [
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  "related_identifiers": [
            
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    {
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    {
            
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      "authors": "Liu Saixi,Shi Wei,Guo Cheng,Zhao Xinguo,Han Yu,Peng 
115
      "authors": "Liu Saixi,Shi Wei,Guo Cheng,Zhao Xinguo,Han Yu,Peng 
            
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Chao,Chai Xueliang,Liu Guangxu",
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Chao,Chai Xueliang,Liu Guangxu",
            
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      "email_authors": ",,,,,,,guangxu_liu@zju.edu.cn",
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      "email_authors": ",,,,,,,guangxu_liu@zju.edu.cn",
            
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      "identifier": "https://doi.org/10.1016/j.fsi.2016.04.030",
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      "identifier": "https://doi.org/10.1016/j.fsi.2016.04.030",
            
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      "identifier_type": "DOI",
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      "identifier_type": "DOI",
            
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      "orcid_authors": 
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      "orcid_authors": 
            
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",0000-0003-0811-2165,,0000-0001-5613-4620,,,,0000-0002-1039-7801",
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",0000-0003-0811-2165,,0000-0001-5613-4620,,,,0000-0002-1039-7801",
            
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      "relation_type": "IsSupplementTo",
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      "relation_type": "IsSupplementTo",
            
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      "source": "Fish & Shellfish Immunology",
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      "source": "Fish & Shellfish Immunology",
            
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      "title": "Ocean acidification weakens the immune response of 
124
      "title": "Ocean acidification weakens the immune response of 
            
125
blood clam through hampering the NF-kappa beta and toll-like receptor 
125
blood clam through hampering the NF-kappa beta and toll-like receptor 
            
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pathways",
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pathways",
            
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      "year": "2016"
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      "year": "2016"
            
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    },
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    },
            
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    {
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    {
            
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      "authors": "Gattuso Jean-Pierre,Epitalon Jean-Marie,Lavigne 
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      "authors": "Gattuso Jean-Pierre,Epitalon Jean-Marie,Lavigne 
            
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H\u00e9lo\u00efse",
131
H\u00e9lo\u00efse",
            
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      "email_authors": 
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      "email_authors": 
            
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"jean-pierre.gattuso@imev-mer.fr,,hlavigne@naturalsciences.be",
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"jean-pierre.gattuso@imev-mer.fr,,hlavigne@naturalsciences.be",
            
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      "identifier": "https://cran.r-project.org/package=seacarb",
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      "identifier": "https://cran.r-project.org/package=seacarb",
            
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      "identifier_type": "DOI",
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      "identifier_type": "DOI",
            
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      "orcid_authors": "0000-0002-4533-4114,,",
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      "orcid_authors": "0000-0002-4533-4114,,",
            
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      "relation_type": "References",
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      "relation_type": "References",
            
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      "source": "",
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      "source": "",
            
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      "title": "seacarb: seawater carbonate chemistry with R. R 
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      "title": "seacarb: seawater carbonate chemistry with R. R 
            
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package version 3.0.8",
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package version 3.0.8",
            
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      "year": "2015"
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      "year": "2015"
            
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    }
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    }
            
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  ],
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  ],
            
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  "relationships_as_object": [],
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  "repository_name": "PANGAEA (Data Publisher for Earth & 
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  "repository_name": "PANGAEA (Data Publisher for Earth & 
            
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Environmental Science)",
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Environmental Science)",
            
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  "resource_type": "text/tab-separated-values - filename: Liu_2016",
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  "resource_type": "text/tab-separated-values - filename: Liu_2016",
            
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  "resources": [],
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  "resources": [],
            
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  "source_metadata_created": "2016",
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  "source_metadata_created": "2016",
            
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  "source_metadata_modified": "",
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  "source_metadata_modified": "",
            
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  "state": "active",
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  "state": "active",
            
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  "subject_areas": [
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  "subject_areas": [
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "BiologicalClassification"
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      "subject_area_name": "BiologicalClassification"
            
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    },
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    },
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Biosphere"
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      "subject_area_name": "Biosphere"
            
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    },
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    },
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Chemistry"
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      "subject_area_name": "Chemistry"
            
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    },
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    },
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Fisheries"
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      "subject_area_name": "Fisheries"
            
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    },
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    },
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Oceans"
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      "subject_area_name": "Oceans"
            
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    }
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    }
            
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  ],
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  ],
            
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  "tags": [
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  "tags": [
            
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    {
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    {
            
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      "display_name": "1000 L or  1 m2",
            
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      "display_name": "Animalia",
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      "display_name": "Animalia",
            
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      "id": "e645e194-a2f7-40f1-ae7c-c1496be6f6bf",
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      "id": "e645e194-a2f7-40f1-ae7c-c1496be6f6bf",
            
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      "name": "Animalia",
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      "name": "Animalia",
            
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "Benthic animals",
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      "display_name": "Benthic animals",
            
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      "id": "ba711ac9-d2d3-4cff-8023-8b85163344bb",
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      "id": "ba711ac9-d2d3-4cff-8023-8b85163344bb",
            
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      "name": "Benthic animals",
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      "name": "Benthic animals",
            
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      "state": "active",
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "Benthos",
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      "display_name": "Benthos",
            
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      "id": "55bc70f2-ff73-4d9a-89f6-16358d0d9b87",
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      "id": "55bc70f2-ff73-4d9a-89f6-16358d0d9b87",
            
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      "name": "Benthos",
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      "name": "Benthos",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "Brackish waters",
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      "display_name": "Brackish waters",
            
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      "id": "a6e90d9c-db5b-4954-9aae-c9e4134fedec",
            
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      "name": "Brackish waters",
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      "name": "Brackish waters",
            
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      "state": "active",
            
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    {
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    {
            
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      "display_name": "Containers and aquaria 20",
            
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      "name": "Containers and aquaria 20-1000 L or  1 m2",
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      "name": "Containers and aquaria 20",
            
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      "state": "active",
            
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    {
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      "state": "active",
            
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    {
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    {
            
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      "name": "Growth",
            
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      "state": "active",
            
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    {
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    {
            
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      "name": "Immunology",
            
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      "state": "active",
            
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    },
            
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    {
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    {
            
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      "display_name": "Laboratory experiment",
            
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      "name": "Laboratory experiment",
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      "name": "Laboratory experiment",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "Mollusca",
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      "display_name": "Mollusca",
            
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      "id": "006d5f6d-11b3-4c34-a35a-879d7cd074c8",
            
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      "name": "Mollusca",
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      "name": "Mollusca",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
            
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    {
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    {
            
n
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      "id": "2345107d-a1a2-43c1-8b38-d670ea499006",
            
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      "name": "Morphology",
            
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
            
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    {
            
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      "display_name": "North Pacific",
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      "display_name": "North Pacific",
            
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      "id": "efbdbaff-aa72-4a57-8e03-e9f84253d644",
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      "id": "efbdbaff-aa72-4a57-8e03-e9f84253d644",
            
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      "name": "North Pacific",
263
      "name": "North Pacific",
            
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
n
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      "display_name": "Self",
            
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      "id": "34b1f942-1c92-4fee-99d1-291bb80232a6",
            
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      "name": "Self",
            
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
            
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    {
            
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      "display_name": "Single species",
275
      "display_name": "Single species",
            
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      "id": "88de69be-3bdd-4cf8-b6a1-386d72c5888d",
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      "id": "88de69be-3bdd-4cf8-b6a1-386d72c5888d",
            
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      "name": "Single species",
277
      "name": "Single species",
            
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      "state": "active",
278
      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
281
    {
            
261
      "display_name": "Tegillarca granosa",
282
      "display_name": "Tegillarca granosa",
            
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      "id": "ba6152fb-3fd8-4359-b969-a3a91aef7c33",
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      "id": "ba6152fb-3fd8-4359-b969-a3a91aef7c33",
            
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      "name": "Tegillarca granosa",
284
      "name": "Tegillarca granosa",
            
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      "state": "active",
285
      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
288
    {
            
268
      "display_name": "Temperate",
289
      "display_name": "Temperate",
            
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      "id": "31aaeb0c-a4a5-4a8e-9c90-be1eff0cac91",
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      "id": "31aaeb0c-a4a5-4a8e-9c90-be1eff0cac91",
            
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      "name": "Temperate",
291
      "name": "Temperate",
            
t
t
292
      "state": "active",
            
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      "vocabulary_id": null
            
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    },
            
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    {
            
296
      "display_name": "protection",
            
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      "id": "64486a5e-aa52-4a3a-9426-fbcf2e3c2721",
            
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      "name": "protection",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
300
      "vocabulary_id": null
            
273
    }
301
    }
            
274
  ],
302
  ],
            
275
  "title": "Ocean acidification weakens the immune response of blood 
303
  "title": "Ocean acidification weakens the immune response of blood 
            
276
clam through hampering the NF-kappa beta and toll-like receptor 
304
clam through hampering the NF-kappa beta and toll-like receptor 
            
277
pathways",
305
pathways",
            
278
  "type": "vdataset",
306
  "type": "vdataset",
            
279
  "url": "https://doi.org/10.1594/PANGAEA.861971"
307
  "url": "https://doi.org/10.1594/PANGAEA.861971"
            
280
}
308
}