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  "author": "Nardi, Alessandro",
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  "author": "Nardi, Alessandro",
            
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  "author_email": "",
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  "author_email": "",
            
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  "citation": [],
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  "citation": [],
            
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  "creator_user_id": "17755db4-395a-4b3b-ac09-e8e3484ca700",
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  "creator_user_id": "17755db4-395a-4b3b-ac09-e8e3484ca700",
            
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  "doi": "10.1594/PANGAEA.887768",
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  "doi": "10.1594/PANGAEA.887768",
            
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  "doi_date_published": "2018",
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  "doi_date_published": "2018",
            
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  "doi_publisher": "",
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  "doi_publisher": "",
            
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  "doi_status": "True",
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  "doi_status": "True",
            
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  "extra_authors": [
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  "extra_authors": [
            
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    {
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    {
            
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      "extra_author": "Benedetti, Maura",
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      "extra_author": "Benedetti, Maura",
            
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      "familyName": "Benedetti",
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      "familyName": "Benedetti",
            
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      "givenName": "Maura",
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      "givenName": "Maura",
            
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      "orcid": "0000-0003-0803-3846"
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      "orcid": "0000-0003-0803-3846"
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Fattorini, Daniele",
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      "extra_author": "Fattorini, Daniele",
            
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      "familyName": "Fattorini",
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      "familyName": "Fattorini",
            
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      "givenName": "Daniele",
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      "givenName": "Daniele",
            
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      "orcid": ""
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      "orcid": ""
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Regoli, Francesco",
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      "extra_author": "Regoli, Francesco",
            
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      "familyName": "Regoli",
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      "familyName": "Regoli",
            
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      "givenName": "Francesco",
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      "givenName": "Francesco",
            
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      "orcid": "0000-0001-6084-6188"
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      "orcid": "0000-0001-6084-6188"
            
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    }
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    }
            
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  ],
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  ],
            
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  "familyName": "Nardi",
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  "familyName": "Nardi",
            
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  "givenName": "Alessandro",
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  "givenName": "Alessandro",
            
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  "groups": [],
            
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  "license_id": "CC-BY-3.0",
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  "license_id": "CC-BY-3.0",
            
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  "license_title": "CC-BY-3.0",
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  "license_title": "CC-BY-3.0",
            
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  "metadata_created": "2024-11-29T11:45:59.516451",
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  "metadata_created": "2024-11-29T11:45:59.516451",
            
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  "metadata_modified": "2024-11-29T11:45:59.516457",
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  "metadata_modified": "2024-11-30T10:43:55.774320",
            
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  "name": "png-doi-10-1594-pangaea-887768",
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  "name": "png-doi-10-1594-pangaea-887768",
            
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  "notes": "Ocean acidification (OA) may affect sensitivity of marine 
40
  "notes": "Ocean acidification (OA) may affect sensitivity of marine 
            
41
organisms to metal pollution modulating chemical bioavailability, 
41
organisms to metal pollution modulating chemical bioavailability, 
            
42
bioaccumulation and biological responsiveness of several cellular 
42
bioaccumulation and biological responsiveness of several cellular 
            
43
pathways. In this study, the smooth scallop Flexopecten glaber was 
43
pathways. In this study, the smooth scallop Flexopecten glaber was 
            
44
exposed to various combinations of reduced pH (pH/pCO2 7.4/3000 
44
exposed to various combinations of reduced pH (pH/pCO2 7.4/3000 
            
45
\u00b5atm) and Cd (20 \u00b5g/L). The analyses on cadmium uptake were 
45
\u00b5atm) and Cd (20 \u00b5g/L). The analyses on cadmium uptake were 
            
46
integrated with those of a wide battery of biomarkers including 
46
integrated with those of a wide battery of biomarkers including 
            
47
metallothioneins, single antioxidant defenses and total oxyradical 
47
metallothioneins, single antioxidant defenses and total oxyradical 
            
48
scavenging capacity in digestive gland and gills, lysosomal membrane 
48
scavenging capacity in digestive gland and gills, lysosomal membrane 
            
49
stability and onset of genotoxic damage in haemocytes. Reduced pH 
49
stability and onset of genotoxic damage in haemocytes. Reduced pH 
            
50
slightly increased concentration of Cd in scallop tissues, but no 
50
slightly increased concentration of Cd in scallop tissues, but no 
            
51
effects were measured in terms of metallothioneins. Induction of some 
51
effects were measured in terms of metallothioneins. Induction of some 
            
52
antioxidants by Cd and/or low pH in the digestive gland was not 
52
antioxidants by Cd and/or low pH in the digestive gland was not 
            
53
reflected in variations of the total oxyradical scavenging capacity, 
53
reflected in variations of the total oxyradical scavenging capacity, 
            
54
while the investigated stressors caused a certain inhibition of 
54
while the investigated stressors caused a certain inhibition of 
            
55
antioxidants and reduction of the scavenging capacity toward peroxyl 
55
antioxidants and reduction of the scavenging capacity toward peroxyl 
            
56
radical in the gills. Lysosomal membrane stability and onset of 
56
radical in the gills. Lysosomal membrane stability and onset of 
            
57
genotoxic damages showed high sensitivity with possible synergistic 
57
genotoxic damages showed high sensitivity with possible synergistic 
            
58
effects of the investigated factors. The overall results suggest that 
58
effects of the investigated factors. The overall results suggest that 
            
59
indirect effects of ocean acidification on metal accumulation and 
59
indirect effects of ocean acidification on metal accumulation and 
            
60
toxicity are tissue-specific and modulate oxidative balance through 
60
toxicity are tissue-specific and modulate oxidative balance through 
            
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different mechanisms.",
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different mechanisms.",
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "created": "2024-11-29T11:32:00.143130",
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    "description": "PANGAEA (Data Publisher for Earth & Environmental 
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    "description": "PANGAEA (Data Publisher for Earth & Environmental 
            
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Science): The information system PANGAEA is operated as an Open Access 
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Science): The information system PANGAEA is operated as an Open Access 
            
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library aimed at archiving, publishing and distributing georeferenced 
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library aimed at archiving, publishing and distributing georeferenced 
            
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data from earth system research. PANGAEA guarantees long-term 
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data from earth system research. PANGAEA guarantees long-term 
            
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availability (greater than 10 years) of its content. PANGAEA is open 
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availability (greater than 10 years) of its content. PANGAEA is open 
            
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to any project, institution, or individual scientist to use or to 
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to any project, institution, or individual scientist to use or to 
            
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archive and publish data. PANGAEA focuses on georeferenced 
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archive and publish data. PANGAEA focuses on georeferenced 
            
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observational data, experimental data, and models/simulations. 
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observational data, experimental data, and models/simulations. 
            
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Citability, comprehensive metadata descriptions, interoperability of 
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Citability, comprehensive metadata descriptions, interoperability of 
            
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data and metadata, a high degree of structural and semantic 
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data and metadata, a high degree of structural and semantic 
            
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harmonization of the data inventory as well as the commitment of the 
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harmonization of the data inventory as well as the commitment of the 
            
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hosting institutions ensures FAIRness of archived data.",
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hosting institutions ensures FAIRness of archived data.",
            
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    "image_url": "pangaea_topicbiosphere.png",
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    "image_url": "pangaea_topicecology.png",
            
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    "name": "pangaea_ecology",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "PANGAEA (Biosphere)",
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    "title": "PANGAEA (Ecology)",
            
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    "type": "organization"
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  "private": false,
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  "publication_year": "2018",
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  "publication_year": "2018",
            
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  "related_identifiers": [
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  "related_identifiers": [
            
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    {
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    {
            
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      "authors": "Nardi Alessandro,Benedetti Maura,Fattorini 
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      "authors": "Nardi Alessandro,Benedetti Maura,Fattorini 
            
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Daniele,Regoli Francesco",
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Daniele,Regoli Francesco",
            
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      "email_authors": "a.nardi@univpm.it,,,f.regoli@univpm.it",
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      "email_authors": "a.nardi@univpm.it,,,f.regoli@univpm.it",
            
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      "identifier": "https://doi.org/10.1016/j.aquatox.2018.01.008",
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      "identifier": "https://doi.org/10.1016/j.aquatox.2018.01.008",
            
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      "identifier_type": "DOI",
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      "identifier_type": "DOI",
            
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      "orcid_authors": 
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      "orcid_authors": 
            
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"0000-0002-9978-1411,0000-0003-0803-3846,,0000-0001-6084-6188",
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      "relation_type": "IsSupplementTo",
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      "relation_type": "IsSupplementTo",
            
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      "source": "Aquatic Toxicology",
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      "source": "Aquatic Toxicology",
            
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      "title": "Oxidative and interactive challenge of cadmium and 
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      "title": "Oxidative and interactive challenge of cadmium and 
            
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ocean acidification on the smooth scallop Flexopecten glaber",
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ocean acidification on the smooth scallop Flexopecten glaber",
            
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      "year": "2018"
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      "year": "2018"
            
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    },
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    },
            
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    {
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    {
            
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      "authors": "Gattuso Jean-Pierre,Epitalon Jean-Marie,Lavigne 
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      "authors": "Gattuso Jean-Pierre,Epitalon Jean-Marie,Lavigne 
            
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H\u00e9lo\u00efse,Orr James C,Gentili Bernard,Proye 
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H\u00e9lo\u00efse,Orr James C,Gentili Bernard,Proye 
            
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Aur\u00e9lien,Soetaert Karline,Rae James",
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Aur\u00e9lien,Soetaert Karline,Rae James",
            
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      "email_authors": 
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      "email_authors": 
            
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,j.orr@iaea.org,bernard.gentili@orange.fr,,karline.soetaert@nioz.nl,",
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,j.orr@iaea.org,bernard.gentili@orange.fr,,karline.soetaert@nioz.nl,",
            
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      "identifier": "https://cran.r-project.org/package=seacarb",
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      "identifier": "https://cran.r-project.org/package=seacarb",
            
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      "identifier_type": "DOI",
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      "identifier_type": "DOI",
            
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      "orcid_authors": 
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4114,,,0000-0002-8707-7080,,,0000-0003-4603-7100,0000-0003-3904-2526",
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      "relation_type": "References",
            
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      "source": "",
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      "source": "",
            
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      "title": "seacarb: seawater carbonate chemistry with R. R 
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      "title": "seacarb: seawater carbonate chemistry with R. R 
            
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package version 3.1",
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package version 3.1",
            
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      "year": "2016"
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  "repository_name": "PANGAEA (Data Publisher for Earth & 
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Environmental Science)",
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Environmental Science)",
            
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Nardi-etal_2018_AT",
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  "resources": [],
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  "source_metadata_created": "2018",
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  "source_metadata_created": "2018",
            
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      "subject_area_additional": "",
            
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      "subject_area_name": "BiologicalClassification"
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      "subject_area_name": "BiologicalClassification"
            
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    },
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Biosphere"
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      "subject_area_name": "Biosphere"
            
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      "name": "Containers and aquaria 20",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
198
    {
            
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      "display_name": "Flexopecten glaber",
199
      "display_name": "Flexopecten glaber",
            
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      "id": "3ae563c2-b316-4789-81bb-69bc2e042a50",
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      "id": "3ae563c2-b316-4789-81bb-69bc2e042a50",
            
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      "name": "Flexopecten glaber",
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      "name": "Flexopecten glaber",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
            
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    {
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    {
            
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      "name": "Immunology-Self-protection",
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      "name": "Immunology",
            
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "Inorganic toxins",
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      "display_name": "Inorganic toxins",
            
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      "id": "f25dcb99-ed5d-4a7a-8861-e8fac59a6346",
            
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      "name": "Inorganic toxins",
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      "name": "Inorganic toxins",
            
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      "state": "active",
            
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      "vocabulary_id": null
            
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    },
            
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    {
            
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      "display_name": "Laboratory experiment",
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      "id": "c6c00754-c769-4932-a517-bff2c9512884",
            
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      "name": "Laboratory experiment",
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      "name": "Laboratory experiment",
            
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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226
    {
            
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      "display_name": "Mediterranean Sea",
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      "display_name": "Mediterranean Sea",
            
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      "id": "3aca1dd8-7465-4a62-a7b5-d877160a2ef6",
            
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      "name": "Mediterranean Sea",
229
      "name": "Mediterranean Sea",
            
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      "state": "active",
230
      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
233
    {
            
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      "display_name": "Mollusca",
            
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      "id": "006d5f6d-11b3-4c34-a35a-879d7cd074c8",
            
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      "name": "Mollusca",
236
      "name": "Mollusca",
            
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      "state": "active",
237
      "state": "active",
            
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      "vocabulary_id": null
238
      "vocabulary_id": null
            
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    },
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    },
            
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    {
240
    {
            
n
n
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242
      "id": "34b1f942-1c92-4fee-99d1-291bb80232a6",
            
243
      "name": "Self",
            
244
      "state": "active",
            
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      "vocabulary_id": null
            
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    },
            
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    {
            
234
      "display_name": "Single species",
248
      "display_name": "Single species",
            
235
      "id": "88de69be-3bdd-4cf8-b6a1-386d72c5888d",
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      "id": "88de69be-3bdd-4cf8-b6a1-386d72c5888d",
            
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      "name": "Single species",
250
      "name": "Single species",
            
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      "state": "active",
251
      "state": "active",
            
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      "vocabulary_id": null
252
      "vocabulary_id": null
            
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    },
253
    },
            
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    {
254
    {
            
241
      "display_name": "Temperate",
255
      "display_name": "Temperate",
            
242
      "id": "31aaeb0c-a4a5-4a8e-9c90-be1eff0cac91",
256
      "id": "31aaeb0c-a4a5-4a8e-9c90-be1eff0cac91",
            
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      "name": "Temperate",
257
      "name": "Temperate",
            
t
t
258
      "state": "active",
            
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      "vocabulary_id": null
            
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    },
            
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    {
            
262
      "display_name": "protection",
            
263
      "id": "64486a5e-aa52-4a3a-9426-fbcf2e3c2721",
            
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      "name": "protection",
            
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      "state": "active",
265
      "state": "active",
            
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      "vocabulary_id": null
266
      "vocabulary_id": null
            
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    }
267
    }
            
247
  ],
268
  ],
            
248
  "title": "Seawater carbonate chemistry and cadmium uptake of the 
269
  "title": "Seawater carbonate chemistry and cadmium uptake of the 
            
249
smooth scallop Flexopecten glaber",
270
smooth scallop Flexopecten glaber",
            
250
  "type": "vdataset",
271
  "type": "vdataset",
            
251
  "url": "https://doi.org/10.1594/PANGAEA.887768"
272
  "url": "https://doi.org/10.1594/PANGAEA.887768"
            
252
}
273
}