CHO stress induced product production

doi:doi:10.25835/0066265

CHO stress induced product production

Carbondioxide feed and macronutrient supply were investigated regarding their effects on cell growth, cell size and cell-specific productivity. Our research reveals a stress related increase in mAb production for carbondioxide limitation, glucose overfeeding and increased glutamate supply as well as the importance of glutamine for proliferation. Together with the discovery of a non-linear correlation between cell enlargement an increased specific productivity, this marks the first step towards better process understanding and optimization.

BibTex:

@dataset{Dörte_Solle_and__Jana_Schellenberg_2021,
    abstract = {Carbondioxide feed and macronutrient supply were investigated regarding their effects on cell growth, cell size and cell-specific productivity. Our research reveals a stress related increase in mAb production for carbondioxide limitation, glucose overfeeding and increased glutamate supply as well as the importance of glutamine for proliferation. Together with the discovery of a non-linear correlation between cell enlargement an increased specific productivity, this marks the first step towards better process understanding and optimization.},
    author = {Dörte Solle and  Jana Schellenberg},
    doi = {10.25835/0066265},
    institution = {Institut für Technische Chemie},
    keyword = {'CHO', 'cell specific production'},
    month = {may},
    publisher = {LUIS},
    title = {CHO stress induced product production},
    url = {https://service.tib.eu/ldmservice/vdataset/luh-cho-stress-induced-product-production},
    year = {2021}
}