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{
            
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  "author": "Feiner, Alexander",
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  "author": "Feiner, Alexander",
            
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  "author_email": "",
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  "author_email": "",
            
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  "citation": [],
            
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  "creator_user_id": "17755db4-395a-4b3b-ac09-e8e3484ca700",
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  "creator_user_id": "17755db4-395a-4b3b-ac09-e8e3484ca700",
            
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  "doi": "10.22000/319",
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  "doi": "10.22000/319",
            
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  "doi_date_published": "2020",
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  "doi_date_published": "2020",
            
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  "doi_publisher": "",
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  "doi_publisher": "",
            
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  "doi_status": "True",
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  "doi_status": "True",
            
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  "extra_authors": [
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  "extra_authors": [
            
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    {
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    {
            
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      "extra_author": "Pitra, Nicholi",
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      "extra_author": "Pitra, Nicholi",
            
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      "familyName": "Pitra",
            
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      "givenName": "Nicholi",
            
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      "orcid": "0000-0001-8642-5138"
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      "orcid": "0000-0001-8642-5138"
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Matthews, Paul",
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      "extra_author": "Matthews, Paul",
            
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      "familyName": "Matthews",
            
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      "givenName": "Paul",
            
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      "orcid": ""
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      "orcid": ""
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Pillen, Klaus",
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      "extra_author": "Pillen, Klaus",
            
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      "familyName": "Pillen",
            
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      "givenName": "Klaus",
            
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      "orcid": ""
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      "orcid": ""
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Wessjohann, Ludger A.",
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      "extra_author": "Wessjohann, Ludger A.",
            
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      "familyName": "Wessjohann",
            
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      "givenName": "Ludger A.",
            
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      "orcid": "0000-0003-2060-8235"
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      "orcid": "0000-0003-2060-8235"
            
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    },
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    },
            
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    {
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    {
            
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      "extra_author": "Riewe, David",
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      "extra_author": "Riewe, David",
            
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      "familyName": "Riewe",
            
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      "givenName": "David",
            
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      "orcid": "0000-0002-9095-5518"
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      "orcid": "0000-0002-9095-5518"
            
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    }
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    }
            
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  ],
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  ],
            
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  "familyName": "Feiner",
            
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  "givenName": "Alexander",
            
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  "groups": [],
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  "groups": [],
            
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  "id": "aadf20e9-6251-440b-ac9d-550737e93140",
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  "id": "aadf20e9-6251-440b-ac9d-550737e93140",
            
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  "isopen": false,
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  "isopen": false,
            
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  "license_id": "CC BY 4.0 Attribution",
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  "license_id": "CC BY 4.0 Attribution",
            
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  "license_title": "CC BY 4.0 Attribution",
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  "license_title": "CC BY 4.0 Attribution",
            
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  "metadata_created": "2023-01-12T13:30:28.386448",
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  "metadata_created": "2023-01-12T13:30:28.386448",
            
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  "metadata_modified": "2023-08-04T09:24:15.613960",
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  "metadata_modified": "2024-11-28T13:14:57.341694",
            
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  "name": "rdr-doi-10-22000-319",
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  "name": "rdr-doi-10-22000-319",
            
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  "notes": "Abstract: Downy mildew in hop (Humulus lupulus L.) is 
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  "notes": "Abstract: Downy mildew in hop (Humulus lupulus L.) is 
            
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caused by Pseudoperonospora humuli and generates significant losses in 
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caused by Pseudoperonospora humuli and generates significant losses in 
            
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quality and yield. To identify the biochemical processes that confer 
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quality and yield. To identify the biochemical processes that confer 
            
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natural downy mildew resistance (DMR), a metabolome- and genome-wide 
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natural downy mildew resistance (DMR), a metabolome- and genome-wide 
            
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association study was performed. Inoculation of a high density 
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association study was performed. Inoculation of a high density 
            
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genotyped F1 hop population (n=192) with the obligate biotrophic 
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genotyped F1 hop population (n=192) with the obligate biotrophic 
            
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oomycete P. humuli led to variation in both the levels of thousands of 
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oomycete P. humuli led to variation in both the levels of thousands of 
            
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specialized metabolites and DMR. We observed that metabolites of 
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specialized metabolites and DMR. We observed that metabolites of 
            
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almost all major phytochemical classes were induced 48 hours after 
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almost all major phytochemical classes were induced 48 hours after 
            
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inoculation. But only a small number of metabolites were found to be 
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inoculation. But only a small number of metabolites were found to be 
            
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correlated with DMR and these were enriched with phenylpropanoids. 
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correlated with DMR and these were enriched with phenylpropanoids. 
            
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These metabolites were also correlated with DMR when measured from the 
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These metabolites were also correlated with DMR when measured from the 
            
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non-infected control set. A genome-wide association study revealed 
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non-infected control set. A genome-wide association study revealed 
            
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co-localization of the major DMR loci and the phenylpropanoid pathway 
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co-localization of the major DMR loci and the phenylpropanoid pathway 
            
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markers indicating that the major contribution to resistance is 
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markers indicating that the major contribution to resistance is 
            
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mediated by these metabolites in a heritable manner. The application 
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mediated by these metabolites in a heritable manner. The application 
            
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of three putative prophylactic phenylpropanoids led to a reduced 
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of three putative prophylactic phenylpropanoids led to a reduced 
            
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degree of leaf infection in susceptible genotypes, confirming their 
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degree of leaf infection in susceptible genotypes, confirming their 
            
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protective activity either directly or as precursors of active 
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protective activity either directly or as precursors of active 
            
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compounds.",
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compounds.",
            
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  "num_resources": 0,
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  "num_resources": 0,
            
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  "num_tags": 6,
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  "num_tags": 6,
            
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  "orcid": "0000-0001-6564-8826",
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  "orcid": "0000-0001-6564-8826",
            
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  "organization": {
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  "organization": {
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "created": "2023-01-12T13:30:23.238233",
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    "created": "2023-01-12T13:30:23.238233",
            
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    "description": "RADAR (Research Data Repository) is a 
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    "description": "RADAR (Research Data Repository) is a 
            
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cross-disciplinary repository for archiving and publishing research 
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cross-disciplinary repository for archiving and publishing research 
            
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data from completed scientific studies and projects. The focus is on 
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data from completed scientific studies and projects. The focus is on 
            
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research data from subjects that do not yet have their own 
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research data from subjects that do not yet have their own 
            
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discipline-specific infrastructures for research data management. ",
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discipline-specific infrastructures for research data management. ",
            
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    "id": "013c89a9-383c-4200-8baa-0f78bf1d91f9",
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    "id": "013c89a9-383c-4200-8baa-0f78bf1d91f9",
            
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    "image_url": "radar-logo.svg",
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    "image_url": "radar-logo.svg",
            
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    "is_organization": true,
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    "is_organization": true,
            
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    "name": "radar",
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    "name": "radar",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "RADAR",
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    "title": "RADAR",
            
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    "type": "organization"
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    "type": "organization"
            
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  },
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  },
            
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  "owner_org": "013c89a9-383c-4200-8baa-0f78bf1d91f9",
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  "owner_org": "013c89a9-383c-4200-8baa-0f78bf1d91f9",
            
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  "private": false,
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  "private": false,
            
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  "production_year": "2015",
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  "production_year": "2015",
            
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  "publication_year": "2020",
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  "publication_year": "2020",
            
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  "publishers": [
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  "publishers": [
            
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    {
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    {
            
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      "publisher": "Simon H. Steiner, Hopfen, GmbH, Mainburg, Germany"
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      "publisher": "Simon H. Steiner, Hopfen, GmbH, Mainburg, Germany"
            
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    },
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    },
            
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    {
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    {
            
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      "publisher": "Leibniz Institute of Plant Genetics and Crop Plant 
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      "publisher": "Leibniz Institute of Plant Genetics and Crop Plant 
            
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Research (IPK), Gatersleben, Germany"
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Research (IPK), Gatersleben, Germany"
            
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    },
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    },
            
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    {
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    {
            
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      "publisher": "Julius Kuehn-Institute (JKI), Berlin, Germany"
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      "publisher": "Julius Kuehn-Institute (JKI), Berlin, Germany"
            
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    },
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    },
            
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    {
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    {
            
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      "publisher": "Leibniz Institute of Plant Biochemistry (IPB), 
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      "publisher": "Leibniz Institute of Plant Biochemistry (IPB), 
            
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Halle (Saale), Germany"
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Halle (Saale), Germany"
            
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    }
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  ],
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  "repository_name": "RADAR (Research Data Repository)",
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  "repository_name": "RADAR (Research Data Repository)",
            
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  "resource_type": "Dataset - MS Peak table",
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  "resource_type": "Dataset - MS Peak table",
            
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  "resources": [],
            
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  "services_used_list": "",
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  "services_used_list": "",
            
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  "source_metadata_created": "2020",
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  "source_metadata_created": "2020",
            
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  "source_metadata_modified": "",
            
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  "state": "active",
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  "state": "active",
            
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  "subject_areas": [
            
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Biochemistry"
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      "subject_area_name": "Biochemistry"
            
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    },
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    },
            
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    {
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    {
            
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      "subject_area_additional": "",
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      "subject_area_additional": "",
            
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      "subject_area_name": "Agriculture"
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      "subject_area_name": "Agriculture"
            
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    }
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    }
            
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  ],
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  ],
            
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  "tags": [
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  "tags": [
            
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    {
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    {
            
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      "display_name": "downy mildew resistance",
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      "display_name": "downy mildew resistance",
            
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      "id": "eb00d134-acff-407d-9361-307bcc40f1e7",
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      "id": "eb00d134-acff-407d-9361-307bcc40f1e7",
            
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      "name": "downy mildew resistance",
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      "name": "downy mildew resistance",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "genome-wide association study",
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      "display_name": "genome-wide association study",
            
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      "id": "e0e5c774-d57a-435e-8418-e86330b7f7a0",
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      "id": "e0e5c774-d57a-435e-8418-e86330b7f7a0",
            
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      "name": "genome-wide association study",
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      "name": "genome-wide association study",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "hop",
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      "display_name": "hop",
            
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      "id": "e2a218b7-02e0-460b-941e-69da131b30aa",
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      "id": "e2a218b7-02e0-460b-941e-69da131b30aa",
            
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      "name": "hop",
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      "name": "hop",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "oomycete",
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      "display_name": "oomycete",
            
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      "id": "3a5b9fd3-a0ba-40e7-bf52-bb5d2421de10",
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      "id": "3a5b9fd3-a0ba-40e7-bf52-bb5d2421de10",
            
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      "name": "oomycete",
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      "name": "oomycete",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "phenylpropanoids",
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      "display_name": "phenylpropanoids",
            
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      "id": "74603eb2-37cc-4f92-bfc8-a0dcb3630b1c",
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      "id": "74603eb2-37cc-4f92-bfc8-a0dcb3630b1c",
            
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      "name": "phenylpropanoids",
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      "name": "phenylpropanoids",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "untargeted metabolomics",
167
      "display_name": "untargeted metabolomics",
            
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      "id": "cfd280db-a29d-4fdb-bcf9-0f5d31e0f746",
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      "id": "cfd280db-a29d-4fdb-bcf9-0f5d31e0f746",
            
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      "name": "untargeted metabolomics",
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      "name": "untargeted metabolomics",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    }
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    }
            
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  ],
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  ],
            
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  "title": "Supplementary data for \"downy mildew resistance is 
174
  "title": "Supplementary data for \"downy mildew resistance is 
            
162
genetically mediated by prophylactic production of phenylpropanoids in 
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genetically mediated by prophylactic production of phenylpropanoids in 
            
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hop\"",
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hop\"",
            
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  "type": "vdataset",
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  "type": "vdataset",
            
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  "url": "https://doi.org/10.22000/319"
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  "url": "https://doi.org/10.22000/319"
            
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}
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}